Contact Information
Fields of Interest
Biography
Champak Chatterjee obtained his Ph.D. in Chemistry (focus on Chemical Biology) from the University of Illinois at Urbana-Champaign and he invented disulfide-directed protein ubiquitylation as a postdoctoral researcher at The Rockefeller University in New York City. The Chatterjee lab in Seattle is developing atom-efficient and water-compatible organic synthetic methodologies for protein chemistry. These new organic and molecular biological methods are applied to understand human gene regulation by reversible post-translational modifications. New trainees in the Chatterjee lab can expect to master techniques in small-molecule, peptide and protein synthesis, bioanalytical and biophysical measurements, molecular biology and mammalian cell culture. Former trainees from the Chatterjee labs have gone onto assistant professorships (Keystone College, PA), startups (Revolution Medicines, CA), postdoctoral research (Harvard Medical School and The Rockefeller University) and lectureships (Baylor University and UW Bothell). The Chatterjee lab is a firm believer in mens sana in corpore sano and hiking is the most popular group activity.
Research
Selected Research
- Chem. Commun., 2023,59, 4063-4066
- Leonen, C.J.A..; Shimada, M.; Weller, C.E.; Nakadai, T.; Hsu, P.L.; Tyson, E.L.; Mishra, A.; Shelton, P.M.M.; Sadilek, M.; Hawkins, R.D.; Zheng, N.; Roeder, R.G.; Chatterjee, C. Sumoylation of the human histone H4 tail inhibits p300-mediated transcription by RNA polymerase II in cellular extracts. Elife 2021, 10:e67952.
- Buckle EL, Sampath J, Michael N, Whedon SD, Leonen CJA, Pfaendtner J, Drobny GP, Chatterjee C. Chembiochem. 2020, 21(22), 3208-3211.
- Dhall A, Shelton PMM, Delachat AM, Leonen CJA, Fierz B, Chatterjee C. Biochemistry. 2020, 59(27), 2479-2483.
- Hsu PL, Shi H, Leonen C, Kang J, Chatterjee C, Zheng N. Mol Cell. 2019, 76(5), 712-723.
- Total Chemical Synthesis of Proteins, John Wiley and Sons, Eds. Brik, Dawson and Liu, 2021, pp 624.
Courses Taught
Winter 2025
Autumn 2024
Spring 2024
Autumn 2023
Winter 2023
Autumn 2022
Winter 2022
CHEM 432/532: Advanced Bio-organic Chemistry (Chemical Biology)