Raymon E. and Rosellen M. Lawton Endowed Professor of Chemistry
Contact Information
CHB 404D
Not accepting PhD students
Not accepting MSACST students
Fields of Interest
Biography
Ph.D. University of California at Berkeley, 2002
Research
Selected Research
- Simon, J. J.; ^Fowler, D. M.; ^Maly, D. J. “Multiplexed profiling of intracellular protein abundance, activity, interactions and druggability with LABEL-seq” Nat. Meth. (2024), 21, 2094-2106.
- Zhang, J. Z.; Ong, S. E.; Baker, D.; Maly D. J. “Single-cell sensor analyses reveal signaling programs enabling Ras-G12C drug resistance” Nat. Chem. Biol. (2024), in press.
- ^Zhang, J. Z.; Nguyen, W.H.; Greenwood, N.; Rose, J. C.; Ong, S-E.; ^Maly, D. J.; ^Baker, D. “Computationally designed sensors detect Ras activity and signaling effectors at subcellular resolution” Nat. Biotech. (2024), in press.
- Chakraborty, S.; Ahler, E.; Simon, J. J.; Fang, L.; Potter, Z. E.; Sitko, K. A.; Stephany, J. J.; Guttman, M.; ^Fowler, D. M.; ^Maly, D. J. “Profiling of drug resistance in Src kinase at scale uncovers a regulatory network coupling autoinhibition and catalytic domain dynamics.” Cell Chem. Biol. (2024), 31, 207-22.
- Wei, C. T.; Popp, N. A.; Peleg, O.; Powell, R. L.; Borenstein, E.; ^Maly, D. J.; ^Fowler, D. M. “A chemically-controlled Cas9 switch enables temporal modulation of diverse effectors” Nat. Chem. Biol. (2023), 19, 981-989.
- Feldman, H. C.; Ghosh, R.; Auyeung, V.; Mueller, J. L.; Kim, J.; Potter, Z. E.; Perera, B. G. K.; Vidadala, V. N.; Olivier, A.; Backes, B. J.; Zikherman, J.; ^Papa, F. R.; ^Maly, D. J. “ATP-Competitive Partial Antagonists of the IRE1α RNase Segregate Outputs of the UPR” Nat. Chem. Biol. (2021), 17, 1148–56.
- Potter, Z. E.; Lau, H-T; Chakraborty, S.; Fang, L.; Guttman, M.; Ong, S-E.; Fowler, D. M.; Maly, D. J. “Parallel Chemoselective Profiling for Mapping Protein Structure” Cell Chem. Biol. (2020), 27, 1084-1096.
- Foight, G. W.; Wang, Z.; Wei, C. T.; Greisen, P. J.; Warner, K.; Cunningham-Bryant, D.; Park, K.; Brunette, T. J.; Sheffler, W.; Baker, D.; Maly, D. J. “Multi-input chemical control of protein dimerization for programming graded cellular responses” Nat. Biotech. (2019), 37, 1209-16.
- Fang, L.; Chakraborty, S.; Dieter, E. M.; Potter, Z. E.; Lombard, C. K.; Maly, D. J. “A Chemoproteomic Method for Profiling Inhibitor-Bound Kinase Complexes” J. Am Chem. Soc. (2019), 141, 11912-11922.
Courses Taught
Spring 2025
Winter 2025
Spring 2024
Winter 2024
Autumn 2023
Spring 2023
Winter 2023
Autumn 2022
Spring 2022
Winter 2022
Affiliations
Home Department