Raymon E. and Rosellen M. Lawton Endowed Professor of Chemistry Contact Information djmaly@uw.edu CHB 404D Personal Website Accepting new graduate students Fields of Interest Chemical Biology Catalysis Organic ChemistryEnzymology Biography Ph.D. University of California at Berkeley, 2002 Research Selected Research Feldman, H. C.; Ghosh, R.; Auyeung, V.; Mueller, J. L.; Kim, J.; Potter, Z. E.; Perera, B. G. K.; Vidadala, V. N.; Olivier, A.; Backes, B. J.; Zikherman, J.; ^Papa, F. R.; ^Maly, D. J. “ATP-Competitive Partial Antagonists of the IRE1α RNase Segregate Outputs of the UPR” Nat. Chem. Biol. 2021, 17, 1148–56. Rose, J. C.; Popp, N. A.; Richardson, C. D.; Stephany, J. J.; Mathieu, J.; Wei, C. T.; Corn, J. E.; ^Maly, D. J.; ^Fowler D. M. “Suppression of unwanted CRISPR/Cas9 editing by co-administration of catalytically inactivating truncated guide RNAs” Nat. Comm. 2020, 11, 2697. Potter, Z. E.; Lau, H-T; Chakraborty, S.; Fang, L.; Guttman, M.; Ong, S-E.; Fowler, D. M.; Maly, D. J. “Parallel Chemoselective Profiling for Mapping Protein Structure” Cell Chem. Biol. 2020, 27, 1084-1096. Foight, G. W.; Wang, Z.; Wei, C. T.; Greisen, P. J.; Warner, K.; Cunningham-Bryant, D.; Park, K.; Brunette, T. J.; Sheffler, W.; Baker, D.; Maly, D. J. “Multi-input chemical control of protein dimerization for programming graded cellular responses” Nat. Biotech. 2019, 37, 1209-16. Fang, L.; Chakraborty, S.; Dieter, E. M.; Potter, Z. E.; Lombard, C. K.; Maly, D. J. “A Chemoproteomic Method for Profiling Inhibitor-Bound Kinase Complexes” J. Am Chem. Soc. 2019, 141, 11912-11922. Feldman, H. C.; Vidadala, V. N.; Potter, Z. E.; Papa, F.R.; Backes, B. J.; Maly, D. J. “Development of a chemical toolset for studying the paralog-specific function of IRE1” ACS Chem. Biol. 2019, 14, 2595-605. Fang, L.; Vilas-Boas, J.; Chakraborty, S.; Potter, Z. E.; Register, A. C.; Seeliger, M. A.; Maly, D. J. “How ATP-competitive inhibitors allosterically modulate tyrosine kinases that contain a Src-like regulatory architecture” ACS Chem. Biol. 2020, 15, 2005-16. Courses Taught Spring 2024CHEM 347 A: Organic and Qualitative Organic Honors LaboratoryWinter 2024CHEM 238 A: Organic ChemistryCHEM 346 A: Organic Chemistry Honors LaboratoryAutumn 2023CHEM 573 A: Current Research Topics in Organic and Biological ChemistrySpring 2023CHEM 347 A: Organic and Qualitative Organic Honors LaboratoryWinter 2023CHEM 238 A: Organic ChemistryCHEM 346 A: Organic Chemistry Honors LaboratoryAutumn 2022CHEM 573 A: Current Research Topics in Organic and Biological ChemistrySpring 2022CHEM 347 A: Organic and Qualitative Organic Honors LaboratoryWinter 2022CHEM 238 A: Organic ChemistryCHEM 346 A: Organic Chemistry Honors LaboratoryCHEM 573 A: Current Research Topics in Organic and Biological ChemistrySpring 2021CHEM 347 A: Organic and Qualitative Organic Honors LaboratoryCHEM 432 A: Advanced Bio-Organic ChemistryCHEM 532 A: Advanced Bio-Organic ChemistryWinter 2021CHEM 346 A: Organic Chemistry Honors Laboratory Affiliations Home Department Chemistry Related Departments Molecular Engineering & Sciences Institute UW Medicine Biochemistry Related News Related News Fellowships, Awards & Honors: Faculty, Staff & Postdocs (June 30, 2023)
