ProfessorRaymon E. and Rosellen M. Lawton Endowed Professor of ChemistryContact Informationdjmaly@uw.eduWebsiteCHB 404DAccepting new graduate students Fields of Interest Chemical BiologyCatalysisOrganic Chemistry BiochemistryEnzymology BiographyPh.D. University of California at Berkeley, 2002Research Selected Research Rose, J. C.; Popp, N. A.; Richardson, C. D.; Stephany, J. J.; Mathieu, J.; Wei, C. T.; Corn, J. E.; ^Maly, D. J.; ^Fowler D. M. “Suppression of unwanted CRISPR/Cas9 editing by co-administration of catalytically inactivating truncated guide RNAs” Nat. Comm. 2020, 11, 2697. Potter, Z. E.; Lau, H-T; Chakraborty, S.; Fang, L.; Guttman, M.; Ong, S-E.; Fowler, D. M.; Maly, D. J. “Parallel Chemoselective Profiling for Mapping Protein Structure” Cell Chem. Biol. 2020, 27, 1084-1096. Foight, G. W.; Wang, Z.; Wei, C. T.; Greisen, P. J.; Warner, K.; Cunningham-Bryant, D.; Park, K.; Brunette, T. J.; Sheffler, W.; Baker, D.; Maly, D. J. “Multi-input chemical control of protein dimerization for programming graded cellular responses” Nat. Biotech. 2019, 37, 1209-16. Fang, L.; Chakraborty, S.; Dieter, E. M.; Potter, Z. E.; Lombard, C. K.; Maly, D. J. “A Chemoproteomic Method for Profiling Inhibitor-Bound Kinase Complexes” J. Am Chem. Soc. 2019, 141, 11912-11922. Feldman, H. C.; Vidadala, V. N.; Potter, Z. E.; Papa, F.R.; Backes, B. J.; Maly, D. J. “Development of a chemical toolset for studying the paralog-specific function of IRE1” ACS Chem. Biol. 2019, 14, 2595-605. Fang, L.; Vilas-Boas, J.; Chakraborty, S.; Potter, Z. E.; Register, A. C.; Seeliger, M. A.; Maly, D. J. “How ATP-competitive inhibitors allosterically modulate tyrosine kinases that contain a Src-like regulatory architecture” ACS Chem. Biol. 2020, 15, 2005-16. Courses Taught Winter 2021 CHEM 346 A: Organic Chemistry Honors Laboratory Spring 2020 CHEM 347 A: Organic and Qualitative Organic Honors Laboratory CHEM 432 A: Advanced Bio-Organic Chemistry CHEM 532 A: Advanced Bio-Organic Chemistry Winter 2020 CHEM 346 A: Organic Chemistry Honors Laboratory Affiliations Affiliated Departments: Molecular Engineering & Sciences InstituteUW MedicineBiochemistry
