Raymon E. and Rosellen M. Lawton Endowed Professor of Chemistry
Fields of Interest
Biography
Ph.D. University of California at Berkeley, 2002
Research
Selected Research
- Simon, J. J.; ^Fowler, D. M.; ^Maly, D. J. “Multiplexed profiling of intracellular protein abundance, activity, interactions and druggability with LABEL-seq” Nat. Meth. (2024), 21, 2094-2106.
- Zhang, J. Z.; Ong, S. E.; Baker, D.; Maly D. J. “Single-cell sensor analyses reveal signaling programs enabling Ras-G12C drug resistance” Nat. Chem. Biol. (2024), in press.
- ^Zhang, J. Z.; Nguyen, W.H.; Greenwood, N.; Rose, J. C.; Ong, S-E.; ^Maly, D. J.; ^Baker, D. “Computationally designed sensors detect Ras activity and signaling effectors at subcellular resolution” Nat. Biotech. (2024), in press.
- Chakraborty, S.; Ahler, E.; Simon, J. J.; Fang, L.; Potter, Z. E.; Sitko, K. A.; Stephany, J. J.; Guttman, M.; ^Fowler, D. M.; ^Maly, D. J. “Profiling of drug resistance in Src kinase at scale uncovers a regulatory network coupling autoinhibition and catalytic domain dynamics.” Cell Chem. Biol. (2024), 31, 207-22.
- Wei, C. T.; Popp, N. A.; Peleg, O.; Powell, R. L.; Borenstein, E.; ^Maly, D. J.; ^Fowler, D. M. “A chemically-controlled Cas9 switch enables temporal modulation of diverse effectors” Nat. Chem. Biol. (2023), 19, 981-989.
- Feldman, H. C.; Ghosh, R.; Auyeung, V.; Mueller, J. L.; Kim, J.; Potter, Z. E.; Perera, B. G. K.; Vidadala, V. N.; Olivier, A.; Backes, B. J.; Zikherman, J.; ^Papa, F. R.; ^Maly, D. J. “ATP-Competitive Partial Antagonists of the IRE1α RNase Segregate Outputs of the UPR” Nat. Chem. Biol. (2021), 17, 1148–56.
- Potter, Z. E.; Lau, H-T; Chakraborty, S.; Fang, L.; Guttman, M.; Ong, S-E.; Fowler, D. M.; Maly, D. J. “Parallel Chemoselective Profiling for Mapping Protein Structure” Cell Chem. Biol. (2020), 27, 1084-1096.
- Foight, G. W.; Wang, Z.; Wei, C. T.; Greisen, P. J.; Warner, K.; Cunningham-Bryant, D.; Park, K.; Brunette, T. J.; Sheffler, W.; Baker, D.; Maly, D. J. “Multi-input chemical control of protein dimerization for programming graded cellular responses” Nat. Biotech. (2019), 37, 1209-16.
- Fang, L.; Chakraborty, S.; Dieter, E. M.; Potter, Z. E.; Lombard, C. K.; Maly, D. J. “A Chemoproteomic Method for Profiling Inhibitor-Bound Kinase Complexes” J. Am Chem. Soc. (2019), 141, 11912-11922.
Courses Taught
Spring 2025
Winter 2025
Spring 2024
Winter 2024
Autumn 2023
Spring 2023
Winter 2023
Autumn 2022
Spring 2022
Winter 2022
Affiliations
Home Department
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