Jesse Zalatan studies the physical organizing principles of biological networks in systems such as cell signaling, metabolism, and gene regulation. His lab uses a variety of methods from fields including physical organic chemistry, mechanistic enzymology, biochemistry, and synthetic biology. Jesse did his graduate work at Stanford University from 2002-2008 with Dan Herschlag, where he developed comparative models to understand mechanism and evolution in enzymes that catalyze phosphoryl transfer reactions. In 2008, he moved to UCSF to join the laboratory of Wendell Lim, where he studied mechanisms for controlling specificity in cell signaling networks. He also developed CRISPR-Cas tools for programmable control of gene expression networks. Jesse joined the chemistry faculty at the University of Washington in 2014.